Wednesday, February 22, 2006

Milestone in miRNA research

Theory
Finding miRNA[6494891, 8252621]
First miRNA in plant
First miRNA in mammal []
Second structure of pri-/pre- miRNA
Mechenism of processing of pri-/pre- miRNA
First discoveries for repressing translation in plant
First discoveries for repressing translation in mammal[8252621, 8252622]
First discoveries for degrading mRNA in plant
First discoveries for degrading mRNA in mammal [15685193, 15105502, 16308420], and then [15685193]
Evolution of miRNA
Mechenism of miRNA function
Promotes Deadenylation of mRNA [16484454, 16495412]
Short RNAs Repress Translation after Initiation in Mammalian Cells [16483934]
Specificity of miRNA
Anti-targets
Concentration determines effective of translation repression
Evidence for seed region of binding between miRNA and its targets in mammal[15014042, 16308420]

Structure of Enzym
Structure of Dicer
Structure of Ago2
Structure Drosha

Technology
prediction of targets of miRNA[14709173, 15723116, 12202040, 15383676(used by miRBASE), 14697198(targetScan), 15806104 (Pictar)]
experimental methods for confirming the targets of miRNA
experimental methods for measureing the concentration of miRNA

Good Reviews
P. Zamore and B. Haley Science. 2005 [16141061]
D. Bartel Cell 2004 [
14744438]