New evidence about random binding of TFs
From: Nature Reviews Genetics 8, 413-423 (June 2007)
As well as providing a genome-wide glimpse of how gene expression is regulated in cis, this study contains a caution against using ChIP data without further evidence of functionality. Importantly, it is now also clear that CRM occupancy must be thought of in quantitative terms, rather than as an on–off state, to fully explore the function of these sites.
ORIGINAL RESEARCH PAPER of this comment: 18271625
As well as providing a genome-wide glimpse of how gene expression is regulated in cis, this study contains a caution against using ChIP data without further evidence of functionality. Importantly, it is now also clear that CRM occupancy must be thought of in quantitative terms, rather than as an on–off state, to fully explore the function of these sites.
ORIGINAL RESEARCH PAPER of this comment: 18271625
posted by Yiming Zhou at 10:45 AM
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