Mediator for transcription

The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.

References:
1. Myers, L C; Kornberg, R D, Mediator of transcriptional regulation, Annual Review Of Biochemistry, 2000, 69:729-749

2. PMID: 15780930

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