How is the activity of transcription factor regulated?

--------- Affect all target genes ---------------
1. Expression of transcription factor.
2. Intracellular translocation of transcription factor.

--------- May only affect a part of target genes ------------
3. Post-translational modification (e.g., phosphorylation and glycosylation) of transcription factor.
4. Binding with other proteins or small molecule.

--------- Affect a part of target genes-----------------
5. Combinations of transcription factor.
6. Compete binding site with repressors.